Protein–Protein Interactions as Targets for Therapeutic Intervention

Our efforts are centered around the targeted modulation of protein–protein interactions (PPIs). PPIs are central to physiological cell function and cellular health, and misregulated PPIs are underlying contributors to the pathogenesis across disease areas. The challenging topologies involved in PPIs leave them an emerging class of targets for pharmaceutical interventions. Using strategic approaches, we leverage peptide synthesis, organic chemistry, mass spectrometry, and molecular and cellular biology to pursue these promising targets.